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[Laughs] ‘It absolutely was unquestionably a great hazard! At some time, I had been very well informed that it could go Mistaken and that I could grow to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Given that 2000, Dekker has shifted the leading focus of his operate to biophysics exactly where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This alteration of area was driven by his fascination for that remarkable functioning of biological molecular constructions, together with via the lengthy-phrase viewpoint a large number of intriguing discoveries is usually expected On this discipline.[5] Recent strains of exploration in his biophysics group are within the areas of:[6]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time examine from the dynamics DNA supercoils and the invention of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you can make this kind of synthetic mobile, would you be ceesdekker a single step nearer to God, or would the function of God have diminished to some degree once again?
Stream-pushed rotary motors such as windmills and water wheels generate practical procedures in human Modern society. Although examples of this kind of rotary motors also attribute prominently in cell biology, their synthetic development for the nanoscale has remained complicated. Here we demonstrate movement-driven rotary motion of a self-organized DNA nanostructure which is docked onto a nanopore in a thin reliable-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking on to the reliable-condition nanopore, and subsequently displays a sustained unidirectional rotary movement of up to twenty rev s−1.
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Bulk-surface coupling identifies the mechanistic connection among Min-protein designs in vivo As well as in vitro
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim from the pore is highlighted in pink, in addition to a 3D rendering with the motion of the DNA rod is displayed.
Cees Dekker is Distinguished College Professor at TU Delft. Experienced to be a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes in the nineteen nineties. Considering the fact that 2000, he moved to one-molecule biophysics and nanobiology. His latest exploration concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is undoubtedly an elected member in the KNAW and fellow for the APS as well as the IOP.
2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; learned an important velocity increase of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of sound in carbon nanotubes in liquid
Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, and a 3D rendering with the motion with the DNA rod is displayed.